Mr. Quark is a down-on-his luck pot-smuggler hiding out in the mountains of Colombia with his dog, High Pockets, and a small band of banditos led by the irascible Jose. Only months before, these three and their fearless associates were rolling in millions in cash and high-grade marijuana, eluding prosecution on "ridiculously false" drug and terrorism charges. But times have quickly grown lean, and to liven up their exile, Jose decides to mug a family of American tourists.

Among the spoils are physics texts, which launch Mr. Quark on a side-splitting, boisterous adventure north to California, where he confronts the owner of the books with his own theories on relativity, the nature of the universe, and looking for the meaning of life in all the wrong places....